G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy

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G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy

Bone marrow necrosis (BMN) is defined as necrosis of the myeloid tissues and stroma without involvement of the cortical bone. We report a case of 66-year-old male with AML-M4 (FAB classification) who was given induction chemotherapy with cytarabine and daunorubicin. Filgrastim at 480 micrograms was administered on days 15-19 to shorten the duration of neutropenia. Consequently patient developed...

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  Background and Objectives: Bone marrow necrosis (BMN) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. This study was performed to identify frequency and the underlying associated diseases of marrow necrosis. Materials and Methods: In this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the Pathology ...

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ژورنال

عنوان ژورنال: Case Reports in Hematology

سال: 2012

ISSN: 2090-6560,2090-6579

DOI: 10.1155/2012/314278